This Biscuit Pizza Casserole is an easy, cheesy dinner made with refrigerated biscuit dough, pizza sauce, pepperoni, sausage, and plenty of melted mozzarella.
Instead of making traditional pizza dough, the biscuits are cut into bite-size pieces and tossed with sauce and toppings before everything bakes together into a bubbly casserole.
The biscuit pieces become fluffy and golden around the edges while soaking up some of the pizza sauce underneath, creating a comforting combination of pizza and casserole in one dish.
It is especially good for busy weeknights, family dinners, game day, potlucks, kids’ meals, or any time you want pizza flavors without making homemade dough.
Why You’ll Love This Recipe
Easy shortcut dinner. Refrigerated biscuits eliminate the need to make pizza dough.
Family-friendly. Pepperoni, cheese, and pizza sauce are familiar favorites.
One-dish meal. Everything bakes together in a casserole dish.
Quick preparation. Most of the work is cutting, mixing, and layering.
Customizable. Add sausage, bacon, mushrooms, peppers, or olives.
Great for parties. Cut into squares or scoop onto plates.
Perfect for leftovers. Reheats well in the oven or air fryer.
Ingredients
Biscuit Base
- 2 cans refrigerated biscuit dough, about 16 ounces each
- 1 tablespoon olive oil
Pizza Filling
- 2 cups thick pizza sauce
- 1 pound Italian sausage, cooked and crumbled
- 1½ cups sliced pepperoni
- 1 small green bell pepper, diced, optional
- ½ small onion, diced, optional
- 1 teaspoon Italian seasoning
- ½ teaspoon garlic powder
Cheese
- 3 cups shredded mozzarella
- 1 cup shredded cheddar or Colby-Jack
- ¼ cup grated Parmesan
Optional Toppings
- Mushrooms
- Black olives
- Jalapeños
- Bacon
- Ham
- Red pepper flakes
- Fresh parsley
Ingredient Notes
Refrigerated Biscuits
Use standard refrigerated biscuit dough.
Flaky-layer biscuits work, but avoid using very large pieces without cutting them down first.
Cutting each biscuit into quarters or sixths helps the dough cook through more evenly.
Pizza Sauce
Use a thick pizza sauce rather than a thin pasta sauce.
Too much watery sauce can make the biscuit pieces soggy.
Italian Sausage
Use fully cooked Italian sausage.
Mild sausage keeps the casserole family-friendly, while hot Italian sausage adds extra spice.
Cook pork sausage thoroughly before adding it to the casserole.
Pepperoni
Standard sliced pepperoni works perfectly.
Mini pepperoni can also be used and distributes more evenly through the casserole.
Cheese
Mozzarella gives the classic pizza cheese pull.
Cheddar or Colby-Jack adds extra flavor, while Parmesan gives the top a salty finish.
How to Make Biscuit Pizza Casserole
Step 1: Preheat the Oven
Preheat oven to:
375°F
Lightly grease a:
9 x 13-inch baking dish.
Step 2: Cook the Sausage
If using Italian sausage, cook it in a skillet over medium heat.
Break it apart while cooking.
Cook until browned and fully cooked.
Drain excess grease.
Step 3: Cut the Biscuits
Separate the refrigerated biscuits.
Cut each biscuit into:
4–6 pieces.
Smaller pieces cook more evenly inside the casserole.
Step 4: Season the Biscuit Pieces
Place the biscuit pieces in a large bowl.
Add:
- Olive oil
- Italian seasoning
- Garlic powder
Toss gently.
Step 5: Add Pizza Sauce
Pour the pizza sauce over the biscuit pieces.
Toss lightly until coated.
Do not completely soak the biscuits.
Step 6: Add Meat and Vegetables
Fold in:
- Cooked sausage
- Most of the pepperoni
- Bell pepper
- Onion
Reserve a little pepperoni for the top.
Step 7: Add Cheese
Stir in:
- 1½ cups mozzarella
- ½ cup cheddar
Mix gently.
Step 8: Transfer to Baking Dish
Spread the mixture evenly in the prepared baking dish.
Avoid packing the biscuit pieces too tightly.
They need room to expand while baking.
Step 9: Add Remaining Cheese
Top with:
- Remaining mozzarella
- Remaining cheddar
- Parmesan
Step 10: Add Pepperoni
Arrange the reserved pepperoni over the cheese.
Step 11: Bake
Bake uncovered for approximately:
30–40 minutes.
The casserole is ready when:
- Cheese is melted
- Top is golden
- Biscuit pieces in the center are cooked through
Step 12: Check the Center
Because biscuit dough can remain soft underneath the cheese, check a piece near the center.
If the dough still looks raw, loosely cover the casserole with foil and continue baking for another:
5–10 minutes.
Step 13: Rest
Remove from the oven.
Let rest for:
5–10 minutes.
Step 14: Serve
Spoon onto plates or cut into portions.
Serve with additional warm pizza sauce if desired.
Expert Tips for the Best Biscuit Pizza Casserole
Cut the biscuits small. Large chunks take much longer to cook through.
Use thick pizza sauce. Thin sauce can make the dough soggy.
Drain sausage well. Excess grease can collect at the bottom.
Don’t overcrowd the dish. Biscuit pieces need room to puff.
Check the center before serving. The edges can look done before the middle is fully baked.
Cover with foil if needed. This lets the center finish without overbrowning the top.
Let it rest. A few minutes of resting makes the casserole easier to serve.
Delicious Variations
Meat Lovers Biscuit Pizza Casserole
Use:
- Italian sausage
- Pepperoni
- Bacon
- Ham
Supreme Pizza Biscuit Casserole
Add:
- Bell peppers
- Mushrooms
- Black olives
- Onion
- Sausage
- Pepperoni
Cheeseburger Pizza Casserole
Replace sausage with browned ground beef.
Add cheddar cheese and diced pickles after baking.
BBQ Chicken Biscuit Pizza Casserole
Replace pizza sauce with barbecue sauce.
Use:
- Cooked shredded chicken
- Red onion
- Mozzarella
- Cheddar
Buffalo Chicken Biscuit Casserole
Use shredded chicken and buffalo sauce.
Top with mozzarella and drizzle with ranch after baking.
Hawaiian Biscuit Pizza Casserole
Add:
- Ham
- Pineapple
- Mozzarella
Drain pineapple very well before using.
Veggie Biscuit Pizza Casserole
Skip the meat and add:
- Mushrooms
- Bell peppers
- Onion
- Spinach
- Olives
Extra-Cheesy Pizza Casserole
Add provolone and extra mozzarella for an even cheesier version.
What to Serve With Biscuit Pizza Casserole
Because this casserole is rich and filling, simple sides work best:
- Green salad
- Caesar salad
- Garlic bread
- Roasted broccoli
- Steamed vegetables
- Coleslaw
- Fresh fruit
For game day, serve it alongside wings, mozzarella sticks, and dipping sauces.
Make Ahead & Meal Prep
The meat and vegetables can be prepared ahead.
Cook the sausage and chop the vegetables up to:
2 days in advance.
Store them separately in the refrigerator.
For best results, assemble the casserole shortly before baking.
Refrigerated biscuit dough can become overly soft if it sits in sauce for too long before going into the oven.
Storage, Freezing & Reheating
Refrigerator
Store cooled leftovers in an airtight container for approximately:
3–4 days.
Freezer
Baked portions can be frozen.
Allow the casserole to cool completely.
Divide into individual servings and freeze in airtight containers.
The biscuit texture may soften slightly after thawing, but the flavor remains good.
Oven Reheating
Reheat at:
350°F
until hot.
Cover loosely with foil if the cheese starts browning too much.
Air Fryer
Individual pieces can be reheated in the air fryer until hot and crisp around the edges.
Microwave
Microwave individual portions in short intervals.
The biscuits will be softer than when reheated in the oven.
Frequently Asked Questions
Can I use refrigerated biscuits for pizza casserole?
Yes. They are the easiest shortcut for this recipe.
Should I bake the biscuits first?
No. Cut the raw biscuit dough into small pieces and bake it directly in the casserole.
Why is the center of my casserole doughy?
The biscuit pieces may have been too large, the casserole may have been packed too tightly, or it may simply need more baking time.
Can I use ground beef instead of sausage?
Absolutely.
Can I make it without pepperoni?
Yes. Use sausage, ground beef, chicken, or vegetables instead.
Can I add vegetables?
Yes. Bell peppers, mushrooms, olives, and onions all work well.
Can I make it ahead?
Prepare the toppings ahead, but assemble with biscuit dough close to baking time.
Can I freeze it?
Yes. Freeze fully baked portions for best results.
Can I use marinara sauce?
Yes, but use a thick marinara and avoid adding too much.
Can I make it spicy?
Yes. Add hot sausage, jalapeños, red pepper flakes, or spicy pepperoni.
Printable Biscuit Pizza Casserole Recipe
Prep Time: 15 minutes
Cook Time: 30–40 minutes
Rest Time: 5–10 minutes
Total Time: About 1 hour
Servings: 6–8
Ingredients
- 2 cans refrigerated biscuit dough
- 2 cups pizza sauce
- 1 pound cooked Italian sausage
- 1½ cups sliced pepperoni
- 1 small bell pepper, optional
- ½ small onion, optional
- 1 teaspoon Italian seasoning
- ½ teaspoon garlic powder
- 3 cups mozzarella
- 1 cup cheddar
- ¼ cup Parmesan
- 1 tablespoon olive oil
Instructions
- Preheat oven to 375°F.
- Grease a 9 x 13-inch casserole dish.
- Cook and drain sausage.
- Cut biscuits into 4–6 pieces each.
- Toss biscuit pieces with olive oil and seasonings.
- Add pizza sauce.
- Fold in sausage, most of the pepperoni, and optional vegetables.
- Add half of the cheese.
- Transfer mixture to baking dish.
- Top with remaining mozzarella, cheddar, and Parmesan.
- Add reserved pepperoni.
- Bake for 30–40 minutes.
- Check the center to make sure biscuit dough is fully cooked.
- Cover loosely with foil and bake 5–10 minutes longer if needed.
- Rest for 5–10 minutes.
- Serve warm with extra pizza sauce.
Final Thoughts
Biscuit Pizza Casserole is an easy way to get all the flavors of a loaded pizza without making traditional pizza dough.
Fluffy biscuit pieces bake together with rich pizza sauce, sausage, pepperoni, and plenty of melted cheese to create a comforting casserole that works especially well for busy weeknights and family dinners.
It is also easy to customize. Make it meat lovers, supreme, barbecue chicken, cheeseburger-style, or completely vegetarian depending on what you have available.